The 7 mm / 20 mm long rigid microendoscope with a diameter of 1.4 mm is based on gradient index (GRIN) lens technology. The endoscope can be easily attached to and removed from laser microscopes and multiphoton tomographs using a magnetic adapter.

The high numerical aperture of 0.8 is capable to provide high submicron resolution images. Autofluorescence, Second Harmonic Generation (SHG), and xenofluorescence can be detected.

The two-photon microendoscope is a high numerical aperture gradient index lens system for:

  • intratissue imaging of small animals
  • clinical imaging of human skin
  • tissue engineering
  • cosmetic research, skin aging
  • in situ drug monitoring
  • stem cell research
  • detection of fluorescent proteins


The microendoscope has been used for small animal research. In particular, optical sectioning of ocular tissue in pigs and mice as well as of intrabody tissues such as liver, intestine, and brain in mice have been performed. Furthermore, clinical studies have been conducted on patients suffering from chronic and acute wounds. The high-NA two photon microendoscope is clinically certified.


König, Ehlers, Riemann, Schenkl, Bückle, Kaatz: Clinical Two-Photon Microendoscopy. Microscopy Research and Technique 70 (2007) 398-402

König, Weinigel, Hoppert, Bückle, Schubert, Köhler, Kaatz, Elsner: Multiphoton tissue imaging using high-NA microendoscopes and flexible scan heads for clinical studies and small animal research. J Biophotonics 1 (2008) 506-513

König: Clinical multiphoton tomography. J Biophotonics 1 (2008) 13-23

Technical data

  • Numerical aperture:0.8
  • Outer diameter [mm]: 1.4
  • Length [mm]: 7/20
  • WD [μm]: 150
  • Horizontal resolution [μm]: 0.87
  • FOV [μm²]: 130x130

PDF-Download: 2P_Endoscope

Note: These specifications are subject to change without notice.

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